Aetna considers the use of metalloporphyrins (e.g., stannsoporfin (tin mesoporphyrin), Stanate, WellSpring Pharmaceutical Corporation, Neptune, NJ) for the treatment of neonatal jaundice experimental and investigational because their safety and effectiveness for this indication has not been established. When the pediatrician spends additional time explaining the skin condition, and the findings affect the episode of care, it should be coded on professional encounters. color: blue!important; Stevenson DK, Wong RJ. } The studies were included if they compared TcB results with TSB in term and near-term infants during phototherapy or after discontinuation of phototherapy. The pooled estimates of correlation coefficients (r) during phototherapy were: covered sites 0.71 (95 % CI: 0.64 to 0.77, 11 studies), uncovered sites 0.65 (95 % CI: 0.55 to 0.74), 8 studies), forehead 0.70 (95 % CI: 0.64 to 0.75, 12 studies) and sternum 0.64 (95 % CI: 0.43 to 0.77, 5 studies). Put a thin layer of clothing, such a T- shirt, on your child's chest. This is usually associated with one of the codes from Q65 Congenital deformities of the hip. The correlation coefficient improved marginally in the post-phototherapy phase (r = 0.72, 95 % CI: 0.64 to 0.78, 4 studies). Yang L, Wu, Wang B, et al. This is caused by a small opening in the abdominal muscles that abdominal contents (e.g., fluid, abdominal lining) spill through. cpt code for phototherapy of newborn Policy Home phototherapy is considered reasonable and necessary for a full-term Nelson Textbook of Pediatrics. Initial hospital or birthing center care, per day, for E/M of normal newborn infant, Initial care per day, for E/M of normal newborn infant seen in other than hospital or birthing center, Initial hospital or birthing center care, per day, for E/M of normal newborn infant admitted and discharged on the same date, Circumsion, using clamp or other device with regional dorsal penile or ring block, Circumsion, as above, without dorsal penile or ring block, Circumsion, surgical excision, other than clamp, device, or dorsal slit, neonate (28 days of age or less), Circumsion, surgical excision, other than clamp, device, or dorsal slit, neonate, old then 28 days of age. One infant (1.6%) met all three AAP guideline criteria of being DAT-positive, bilirubin within 3 of exchange level, and rising bilirubin despite intensive phototherapy. Curr Opin Pediatr. In a Cochrane review, Thomas et al (2007) stated that neonates from isoimmunized pregnancies have increased morbidity from neonatal jaundice. Starting Feb. 1, 2022, five new CPT codes will require preauthorization. Saunders Co.; 2000:513-519. Inpatient coders dont collect watchful waiting conditions. Until the lacrimal ducts drain spontaneously, the pediatrician can show the parents a massage technique to use between the bridge of the nose and the inside corner of the affected eye. } They performed a systematic review of RCTs of probiotic supplementation for prevention or treatment of jaundice in neonates (any gestation or weight) using the Cochrane methodology. With time, the lacrimal ducts mature and the membrane covering the nasolacrimal ducts open. Two reviewers screened papers and extracted data from selected papers. Since then, many hundred thousand infants have been treated with light. Aetna considers measurement of end-tidal carbon monoxide (CO) corrected for ambient CO (ETCOc), used either alone or in combination with the simultaneous measurement of total serum bilirubin (TSB) concentration, experimental and investigational because measurement of ETCOc has not been proven to improve prediction of development of significant neonatal bilirubinemia over TSB alone. Various trials in pregnant women who were not isoimmunized but had other risk factors for neonatal jaundice have shown a reduction in need for phototherapy and exchange transfusion by the use of antenatal phenobarbital. These investigators evaluated the effects of antenatal phenobarbital in red cell isoimmunized pregnancies in reducing the incidence of phototherapy and exchange transfusion for the neonate. Severe hyperbilirubinemia was used as a surrogate for possible chronic bilirubin encephalopathy (CBE), because no studies directly evaluated the latter as an outcome. The ICD-10-PCS code for light treatment of the skin is 6A600ZZ Phototherapy of skin, single for a single treatment. Data were extracted and analyzed independently by 2 review authors (MG and HM). In those (uncommon) circumstances, report P83.5 Congenital hydrocele. Notes: Prophylactic phototherapy is considered medically necessary for infants showing a rapid rise in bilirubin (greater than 1 mg/dL/hour) and as a temporary measure when one is contemplating exchange transfusion. Paediatrics Child Health. It involves the exposure of the newborn to an ultraviolet light source (bili-light) in the home for a prescribed period of time. The Cochrane tool was applied to assessing the risk of bias of the trials. Aetna's policy on treatment of hyperbilirubinemia in infants is adapted from guidelines from the American Academy of Pediatrics. 2013;89(5):434-443. Systematic review of global clinical practice guidelines for neonatal hyperbilirubinemia. There was no difference in the treatment efficacy and TSB, while there was a significant difference in phototherapy duration and side effects after treatment of intermittent phototherapy and continuous phototherapy for neonatal hyperbilirubinemia. 1992;89:809-818. The ointment is administered by the hospital staff, so there is no professional component to the service. This is not a reportable inpatient condition. 2008;359(18):1885-1896. A fetus blood is different than an adults. Lazar L, Litwin A, Nerlob P. Phototherapy for neonatal nonhemolytic hyperbilirubinemia. The beroptic system consists of a pad of This study compared oral zinc with placebo. ICD-10 Restricts Same-day Sick and Well Visits. 5 star restaurants st louis. Home Phototherapy for Neonatal Jaundice (07.06.02) COVERED: ACCORDING TO CERTAIN CRITERIA Phototherapy is often used to treat neonatal jaundice and involves the continuous application of ultraviolet light via a lamp or a beroptic system to a newborn for a prescribed period of time. In most of the trials, Field massage was given; 6 out of 8 trials reported reduction in bilirubin levels in term neonates. } background: #5e9732; 'New' bilirubin recommendations questioned. Pediatrics. Cryptorchidism color: #FFF; Pediatrics. Per the ICD-10-PCS Official Guidelines for Coding and Reporting, only clinically significant conditions are reported. Revision Log See Important Reminder . Rates of death in the aggressive-phototherapy and conservative-phototherapy groups were 24 % and 23 %, respectively (relative risk, 1.05; 95 % CI: 0.90 to 1.22). The provider should document whether the testis is ectopic (e.g., in the superficial inguinal pouch) or abdominal. There is insufficient evidence to support the use of metalloporphyrins (e.g., stannsoporfin (tin mesoporphyrin), Stanate, WellSpring Pharmaceutical Corporation, Neptune, NJ) for the treatment of neonatal jaundice. These investigators reviewed the current literature to examine if home-based phototherapy is more effective than hospital-based phototherapy for the treatment of neonatal hyperbilirubinemia. 99238-99239 _____ 99463 Normal Newborn evaluated & discharged same day 9 Normal Newborn Care 99460 Initial hospital or birthing center care- normal newborn OL LI { 2002;65(4):599-606. 202;11(1):e040182. 7. There are implications for future healthcare needs (e.g., having a specialty consult ordered prior to discharge). Lets review which conditions should be reported and when. One study reported a significant reduction in the risk of hyperbilirubinemia and rate of treatment with phototherapy associated with enteral supplementation with prebiotics (RR 0.75, 95 % CI: 0.58 to 0.97; 1 study, 50 infants; low-quality evidence). Chawla D, Parmar V. Phenobarbitone for prevention and treatment of unconjugated hyperbilirubinemia in preterm neonates: A systematic review and meta-analysis. This risk increased significantly in the CC genotype carriers at the rs4149056 locus of the SLCO1B1 gene (OR=2.17, 95 % CI: 1.87 to 2.33), whereas it decreased significantly in individuals carrying the G-allele at the rs699512 locus of the BLVRA gene (adjusted OR=0.84, p= 0.01, 95 % CI: 0.75 to 0.95). Natus Medical Inc. ETCOc - An indicator of elevated hemolysis in neonatal hyperbilirubinemia. In: BMJ Clinical Evidence. Meta-analysis (random-effects model) showed probiotic supplementation reduced duration of phototherapy [n=415, MD: -11.80 (-17.47 to -6.13); p<0.0001; level of evidence (LOE): low]; TSB was significantly reduced at 96hours [MD: -1.74 (-2.92 to -0.57); p=0.004] and 7 days [MD: -1.71 (-2.25 to -1.17); p<0.00001; LOE: low] after probiotic treatment. newborn, known as hyperbilirubenemia. The SLCO1B1 521 T>C mutation showed a low risk of neonatal hyperbilirubinemia in Chinese neonates, while no significant associations were found in Brazilian, white, Asian, Thai, and Malaysian neonates. Petersen and colleagues (2014) stated that extreme hyperbilirubinemia (plasma bilirubin greater than or equal to 24.5 mg/dL) is an important risk factor for severe bilirubin encephalopathy. After maintenance phototherapy was discontinued, 7 patients (23% ) had a sustained disease-free interval lasting more than 58 months (median of greater than 90 months). Oral zinc for the prevention of hyperbilirubinaemia in neonates. These researchers performed a systematic review with meta-analysis including genetic studies, which assessed the association between neonatal hyperbilirubinemia and 388 G>A, 521 T>C, and 463 C>A variants of SLCO1B1 between January of 1980 and December of 2012. Compared with hospital-based phototherapy, home-based phototherapy appeared more effective for the treatment of neonatal hyperbilirubinemia in reducing the rate of total serum bilirubin (standard mean difference [SMD] = 0.32, 95 % CI: -0.22 to 0.86, p = 0.04); however, there was no signicant difference in duration of phototherapy (SMD = 0.59, 95 % CI: 0.28 to 0.90, p = 0.06) in the 2 groups. 2010;(1):CD001146. These investigators included trials where neonates with hyperbilirubinemia received either clofibrate in combination with phototherapy or phototherapy alone or placebo in combination with phototherapy. Bilirubin recommendations present problems: New guidelines simplistic and untested. The authors concluded that in this study population, GS polymorphism alone did not appear to play a major role in severe neonatal hyperbilirubinemia in neonates without signs of hemolysis. It suggested that these researchers should use the same guideline to detect the time of jaundice fading in future study. The code is valid for the year 2023 for the submission of HIPAA-covered transactions. 04/29/2022 The UGT1A1*28 allele was assessed in a case-control study of 231 white infants who had extreme hyperbilirubinemia in Denmark from 2000 to 2007 and 432 white controls. TcB should not be used in patients undergoing phototherapy.". Li and colleagues (2019) examined the associations between G6PD 1388 G>A, SLCO1B1 rs4149056 and BLVRA rs699512 variants and the risk of neonatal hyperbilirubinemia in a Chinese neonate population. The longer the newborn has before an auditory function screening, the greater the chance of a successful screening. Date of Last Revision: 10/22 . The following are general age-in-hours specifictotal serum bilirubin (TSB)threshold values for phototherapy based upon gestational age and the presence or absence of risk factors (isoimmune hemolytic disease, glucose-6-phosphate dehydrogenase [G6PD] deficiency, asphyxia, significant lethargy, temperature instability, sepsis, acidosis, or albumin of less than 3.0 g/dL [if measured]): Footnotes* Low Risk: 38 weeks gestation and without risk factors; Medium Risk: 38 weeks gestation with risk factors or 35 to 37 6/7 weeks gestation without risk factors; High Risk: 35 to 37 6/7 weeks gestation with risk factors. } Cochrane Database Syst Rev. 1995;96(4 Pt 1):727-729. 2003;88(6):F459-F463. A total of 10 publications (11 studies) were eligible. Some watchful waiting conditions include: Some conditions happen more frequently in premature newborns such as cryptorchidism and umbilical hernias. The initial day of critical care for the evaluation and management of a critically ill neonate, 28-days of age or less, is reported with code 99468. In that case, other conditions can be coded if they were involved in medical decision-making, or otherwise affected the episode of care. Am Fam Physician. Intensive phototherapy in form of double light is used worldwide in the treatment of severe neonatal hyperbilirubinemia. Aetna Inc. and its subsidiary companies are not responsible or liable for the content, accuracy, or privacy practices of linked sites, or for products or services described on these sites. Ip S, Glicken S, Kulig J, et al. padding: 10px; 2012;12:CD009017. There were no reports of the need for exchange transfusion and incidence of acute bilirubin encephalopathy, chronic bilirubin encephalopathy, and major neurodevelopmental disability in the included studies. 66920 Removal of lens material; intracapsular. Other methods, such as enteral feeding supplementation with prebiotics, may have an effective use in the management of hyperbilirubinemia in neonates. An alternative to prolonged hospitalization of the full-term, well newborn. With the sleeve pinned to the t-shirt, the newborn has restricted arm movement, and the clavicle heals without intervention. A total of 10 articles were included in the study. The dose of zinc varied from 5 to 20mg/day and duration from 5 to 7 days. The genotype of Gilbert syndrome, the UGT1A1*28 allele, causes markedly reduced activity of this enzyme, but its association with neonatal hyperbilirubinemia is uncertain and its relationship with extreme hyperbilirubinemia has not been studied. Pediatrics. Liu J, Long J, Zhang S, et al. Ludwig MA. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were used for reporting methods and results of synthesis with meta-analysis. Infants had been treated with DXM (0.25 mg/kg twice-daily at postnatal day 1 and 2) or with placebo (normal saline). Evaluation and treatment of jaundice in the term infant: A kinder, gentler approach. Guidelines from the AAP stated: "There is now evidence that hyperbilirubinemia can be effectively prevented or treated with tin-mesoporphyrin, a drug that inhibits the production of heme oxygenase. 2018;31(10):1311-1317. Phototherapy was started at an average of 7 h of age, and the first IVIG dose was administered at an average of 13 h of life; nearly 25% received a second IVIG dose. Each payer can develop its own diagnosis-related group. Clin Pediatr (Phila). Guidelines for Perinatal Care. These researchers conducted a systematic review of studies comparing TcB devices with TSB in infants receiving phototherapy or in the post-phototherapy phase. Diagnosis code Z00.121 (encounter for routine child health examination with abnormal findings) and the appropriate problem diagnosis would be used. Both case and control subjects were full term newborns. When the observation of hip click does not lead to diagnostic testing (e.g., ultrasound), therapeutic treatment (e.g., parental training in the use of, and discharged with, a Pavlik harness), an inpatient specialty consult, neonatal intensive care, or a scheduled outpatient specialty consult, it is not coded by inpatient coders. Furthermore, an UpToDate review on "Evaluation of unconjugated hyperbilirubinemia in term and late preterm infants" (Wong and Bhutani, 2017) states that "TcB measurements are not reliable in infants undergoing phototherapy. The authors concluded that intermittent phototherapy appeared to be as effective as continuous phototherapy for the treatment of neonatal hyperbilirubinemia and was safer than continuous phototherapy. The authors concluded that there are insufficient data from different countries on the use of clofibrate in combination with phototherapy for hyperbilirubinemia to make recommendations for practice. In preterm infants, phototherapy should be initiated at 50 to 70 % of the maximum indirect levels below: Footnotes* Complications include but are not limited to prenatal asphyxia, acidosis, hypoxia, hypoalbuminemia, meningitis, intraventricular hemorrhage, hemolysis, hypoglycemia, or signs of kernicterus. 1994;94(4 Pt 1):558-565 (reviewed 2000). J Perinatol. Phototherapy is the use of visible light to treat severe jaundice in the neonatal period. 2019;68(1):E4-E11. Montreal, QC: CETS; October 2000. Screening of infants for hyperbilirubinemia to prevent chronic bilirubin encephalopathy: US Preventive Services Task Force recommendation statement. Testicles develop in the abdomen. Some studies showed that unclear random allocation and allocation plan might exaggerate the hidden effect of up to 30 to 41 %. Study authors were contacted for additional information. Last Review04/29/2022. Hayes Directory. 2019;8:CD012731. At the well-baby check, report K42.9 Umbilical hernia without obstruction or gangrene if the condition is addressed (not merely noted in the documentation). When the depression is too shallow, the femoral head may move around in the depression and sometimes move out of the acetabulum. Data selection and extraction were performed independently by 2 reviewers. OL OL OL OL OL LI { Aetna does not provide health care services and, therefore, cannot guarantee any results or outcomes. Approximately 2 ml of peripheral venous blood was taken from all subjects. Home-based phototherapy versus hospital-based phototherapy for treatment of neonatal hyperbilirubinemia: A systematic review and meta-analysis. These researchers examined whether the UGT1A1*28 allele is associated with extreme hyperbilirubinemia. These researchers stated that healthcare organizations and health workers should choose intermittent phototherapy as the preferred therapy for neonatal hyperbilirubinemia. Coding for this service depends on the provider of the service and whether the visit is in follow-up to an already identified problem or screening for problems. An example is hemangiomas (e.g., strawberry hemangiomas), which do not impinge on vital structures and are not located in the periorbital area, lip, neck, or sacral region. Clinical Information. Watchko and Lin (2010) noted that the potential for genetic variation to modulate neonatal hyperbilirubinemia risk is increasingly being recognized. Pediatrics. Petersen JP, Henriksen TB, Hollegaard MV, et al. The linear regression analysis showed a better correlation between BiliCheck and serum bilirubin (r = 0.75) than between BiliMed and serum bilirubin (r = 0.45). If the abnormal results lead to diagnostic testing, they should be coded on an inpatient record. Honar et al (2016) found that ursodiol added at the time of phototherapy initiation showed a significant reduction in peak bilirubin levels and duration of phototherapy in term infants with unconjugated hyperbilirubinemia without any adverse effects. Place the thermometer in your newborn's armpit while the phototherapy lights are on. Aetna considers genotyping of BLVRA, SLCO1B1 and UGT1A1 experimental and investigational for assessing risk of neonatal hyperbilirubinemia because the clinical value of this approach has not been established. For well infants 35 - 37 6/7 wk, can adjust TSB levels for intervention around the medium risk line. The RR or MD with a 95 % CI was used to measure the effect. Family physicians who perform newborn circumcision should separately report this service. NY State J Med. For more information about cryptorchidism, visit: ncbi.nlm.nih.gov/pubmed/10932966. Available at: http://www.emedicine.com/med/topic1065.htm. Language services can be provided by calling the number on your member ID card. Normal Newborn visit, initial service 1. In: Nelson Textbook of Pediatrics. There was diagnostic testing or a specialty inpatient consult; or. Gholitabar M, McGuire H, Rennie J, et al. Prophylactic phototherapy for preventing jaundice in preterm or low birth weight infants. The rate of neurodevelopmental impairment alone was significantly reduced with aggressive phototherapy. The influence of zinc sulfate on neonatal jaundice: A systematic review and meta-analysis. They stated that there is a need for larger trials to determine how effective clofibrate is in reducing the need for, and duration of, phototherapy in term and preterm infants with hyperbilirubinemia. If done right, you will hear a popping sound. Total serum bilirubin concentrations peaked 30 hours earlier in the DXM group (p 0.05). Polymerase chain reaction analysis on blood spot was performed to determine the frequency of UGTA1A1 promoter polymorphisms in cases and controls. FN07-02. 2008;93(2):F135-F139. As a family physician, you may also address needs of the mother during a newborn's encounter (e.g., lactation problems). Inpatient coders do not code immature lacrimal ducts because the condition does not use additional resources. Trikalinos et al (2009) reviewed the effectiveness of specific screening modalities to prevent neonatal bilirubin encephalopathy. } The efficacy of intravenous fluid supplementation for neonatal hyperbilirubinemia: A meta-analysis of randomized controlled studies. They considered all RCTs that studied neonates comparing enteral feeding supplementation with prebiotics versus distilled water/placebo or no supplementation. The lining of the abdomen pouches into the scrotum to surround the testicle. Deshmukh and associates (2017) noted that neonatal jaundice requiring phototherapy is associated with significant socioeconomic burden including hospital re-admission, prolonged hospital stay, and separation of the baby from mother. Cases were identified in the Danish Extreme Hyperbilirubinemia Database that covers the entire population. Two reviewers independently assessed studies for inclusion, and discrepancies were resolved with consensus. These services include intensive cardiac and respiratory monitoring, continuous and/or frequent vital sign monitoring, heat maintenance, enteral and/or parenteral nutritional adjustments, laboratory and oxygen monitoring, and constant observation by the health care team under direct physician supervision. 2010;15(3):164-168. Prediction of hyperbilirubinemia in near-term and term infants. Search All ICD-10 Toggle Dropdown. Two studies also provided results as Bland-Altman difference plots (mean TcB-TSB differences -29.2 and 30 mol/L, respectively). The China National Knowledge Infrastructure and MEDLINE databases were searched. However, if significant time beyond that typical of the infant preventive service is spent in counseling, physicians may also report a problem-oriented service (99212-99215) with modifier -25 to indicate the significant and separately identifiable services provided on the same date. These findings seem compatible with the concept that factors other than bilirubin conjugation capacity are important for the pathophysiology of neonatal jaundice in ELBW preterm infants. solute carrier organic anion transporter polypeptide 1B1 (SLCO1B1)] may interact with each other and/or environmental contributors to produce significant hyperbilirubinemia. Tin-mesoporphyrin is not approved by the U.S. Food and Drug Administration. 2006;117(2):474-485. 2. The authors concluded that genetic variants of bilirubin metabolism genes, including G6PD 1388 G>A, SLCO1B1 rs4149056 and BLVRA rs699512, were associated with the risk of neonatal hyperbilirubinemia, and are potential markers for predicting the disorder. Evidence Report/Technology Assessment No. They stated that further research is needed before the use of TcB devices can be recommended for these settings. Randomized, controlled trial of early intravenous nutrition for prevention of neonatal jaundice in term and near-term neonates. Description For inpatient hospital coding, a condition is clinically significant if it requires: Note: These perinatal guidelines are the same as the general coding guidelines for additional diagnoses, except for the final point regarding implications for future healthcare needs. Published March 24, 2016 (updated June 1 2, 2018). 1994;61(5):424-428. PubMed, Embase, Web of science, EBSCO, Cochrane library databases, Ovid, BMJ database, and CINAHL were systematically searched; RCTs evaluating the effect of zinc sulfate versus placebo on the prevention of jaundice in neonates were included. Search All ICD-10; ICD-10-CM Diagnosis Codes; ICD-10-PCS Procedure Codes Dennery PA. Metalloporphyrins for the treatment of neonatal jaundice. The following are general age-in-hours specificTSBthreshold values forexchange transfusionbased upon gestational age and the presence or absence of risk factors (isoimmune hemolytic disease, glucose-6-phosphate dehydrogenase [G6PD] deficiency, asphyxia, significant lethargy, temperature instability, sepsis, acidosis, or albumin ofless than 3.0 g/dL [if measured]): Footnotes* Low Risk: 38 weeks gestation and without risk factors; Medium Risk: 38 weeks gestation with risk factors or 35 to 37 6/7 weeks gestation without risk factors; High Risk: 35 to 37 6/7 weeks gestation with risk factors. Maisels MJ, McDonagh AF. 2007;(2):CD005541. Clinical Policy Bulletins are developed by Aetna to assist in administering plan benefits and constitute neither offers of coverage nor medical advice. Some watchful waiting issues require continued outpatient evaluation until resolution. Understanding why a pediatrician documents a finding enables you to determine if it should be coded. Halliday HL, Ehrenkranz RA, Doyle LW. Learn how we are healing patients through science & compassion, Stanford team stimulates neurons to induce particular perceptions in mice's minds, Students from far and near begin medical studies at Stanford. Some infants may require intensive care services but do not meet the CPT definition of critically ill or injured required for reporting of critical care services. 66850 Removal of lens material; phacofragmentation technique (mechanical or ultrasonic) (eg, phacoemulsification), with aspiration. When a baby is born, we all hope he or she can be coded with a 99431 (History and examination of the normal newborn infant, initiation of diagnostic and treatment programs and preparation of hospital records). 6. www.stanfordchildrens.org/en/topic/default?id=developmental-dysplasia-of-the-hip-ddh-90-P02755 hip dysplasia 2006;(4):CD004592. Garg BD, Kabra NS, Balasubramanian H. Role of massage therapy on reduction of neonatal hyperbilirubinemia in term and preterm neonates: A review of clinical trials. The G6PD 1388 G>A, SLCO1B1 rs4149056 and BLVRA rs699512 SNPs had a significant impact on STB levels. If separately documented in the mother's chart, you may report these services in addition to the services provided to the infant. 1998;101(1 Pt 1):25-31. In a Cochrane review on early (less than8 days) postnatal corticosteroid treatmentfor preventing chronic lung disease in preterm infants, Halliday et al(2010) concluded that the benefits of early postnatal corticosteroid treatment, especially DXM, may not out-weigh the known or potential adverse effects of this treatment. Even if it meets the technical meaning of conjunctivitis (inflammation of the conjunctiva), it isnt contagious; its self-limiting and does not affect medical decision-making, so it cannot be coded on the pediatricians encounter.

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