There are two types of this condition, summer-pasture-associated and classic recurrent airway obstruction (RAO). Diphenhydramine can alter the results of skin allergy testing; discontinue this medication at least 2 weeks before testing. The dose of Apoquel is 0.4-0.6 mg/kg every 12 hours for up to 14 days, then 0.4-0.6 mg/kg once daily thereafter. Adverse events were reported in less than 5% of dogs, including urinary tract infection, vomiting, otitis, pyoderma, and diarrhea. 3. Milder cases of asthma are still associated with coughing, airway inflammation, mucous production, and poor performance.. Shes on 5 pills once a day for 7 days, after that we will drop to every other day, and then see how far we can space it out. Apoquel should not be used in breeding, pregnant, or lactating dogs. The dose of Apoquel tablets is 0.18-0.27 mg/lb (0.4-0.6 mg/kg). Treatment should be started at a dose of 0.4 - 0.6 mg per kilogram bodyweight twice a day for up to two weeks. Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. Meaning, if a 100lbs dog gets 16mg (1 pill), a horse does not need 160mg (10 pills). In cats, this medication can cause excitement rather than sedation. 15. Find out more. Although no studies of pharmacokinetics in cats have been published, oclacitinib is well tolerated and seems to be safe when used in cats at 1 or 2 mg/kg q12h for 28 days.21 Further studies are needed to investigate adverse effects associated with long-term use in cats. Rabies in Animals. @vxf111 we were told the same thing for food allergiesthat they did not make serums fot them because they were not very effecttive and the the expectation was that the allergen be removed from the diet. Cochet Faivre N, Degorce-Rubiales F. Clinical eosinophilic popular dermatitis associated with histological eosinophilic granuloma rapidly responsive to oclacitinib in an adult Labrador retriever. Several of their drugs are eligible. This gives you the total number of milligrams for the dose for your horse. Pet owners should visit ZoetisPetcare.com for product info, rewards and support. More severe ones, however, can truly take a toll on your horses health and make him miserable. Clenbuterol dilates the airways, and may improve air flow, but it doesn't treat the inflammation associated with the disease. Skin allergies can also cause pruritus (itching) and associated hair loss. Rarely, dogs on Apoquel develop new skin masses; however, a long-term study found no association between Apoquel and the development of malignant cancer. Vet Dermatol 2016;27(1):22-e7. The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. Apoquel is used to treat and control itching and inflammation in dogs resulting from a variety of causes, including environmental allergies, food allergies, flea allergy, and contact allergies. Meaning, if a 100lbs dog gets 16mg (1 pill), a horse does not need 160mg (10 pills). Apoquel is an anti-allergy drug that's often prescribed by vets. In atopic dermatitis, it is mainly mediated by a large group of proinflammatory and proallergic Th2 cytokines (e.g., interleukin [IL]-4, IL-5, IL-10, IL-13, IL-31). I paid $250 for 100 pills (thats 20 5-pill doses). holy crapola batman- just had to put my dog back on it (Hes usually on it April through Nov but with the weird weather we got away with waiting until July thankfully) and saw the price increase- yikes! Uses for Apoquel Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. Collard WT, Hummel BD, Fielder AF, et al. Join us as we interview leading equine researchers from the University of Kentucky, Problem Solver Series: How to Control Nuisance Birds on Horse Properties. Depending on the size of a cat and the condition being treated, a veterinarian may elect to alter the dosage. J Vet Pharmacol Ther 2014;37(3):279-285. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel) in client-owned dogs with atopic dermatitis. Excitement rather than lethargy can occur occasionally, especially in cats. 1. 3 Can be used for long-term maintenance or short-term therapy in dogs 12 months of age . Vet Dermatol 2015;26(1):23-30, e7-8. Her lifelong love of horses motivated her to adopt her college care horse, Claire, upon graduation. Thereafter the dose should be reduced to once daily for maintenance. The anti-inflammatory effects of dexamethasone are about twenty-five times stronger than those of natural cortisol. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. However, a small subcategory of asthmatic horses suffer from pasture-associated equine asthma. Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. Dexamethasone is a synthetic corticosteroid hormone used to manage inflammation in diseases or conditions in which the immune system has a significant role. Adding an update here in case its helpful for others. I have not tried to go less than that. At that point, the treatment can be changed to oclacitinib. Barns can also have noxious gases from the ammonia in urine. All dogs itch sometimes, but when you notice it happening more and more, it could be a sign of a medical condition. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction. Do not use in breeding, pregnant, or lactating dogs. 9. The mare luckily didnt have a lot of food allergies and eliminating flax wasnt a big deal. Why were losing our horse doctors and how to begin solving the problem. Now divide the 10,000 mg by the 500 mg in the concentration. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. 24. The dose range is very strict, I do not recommend going above the recommended dose due to immune suppression, below the range and it doesn't seem to work in most cases. For this first stretch, thats not going to get me too far since I need the loading dose up front. Dr. Patrick Hensel is a 1996 graduate of the University of Bern, Switzerland. She is a New-York-based freelance author with a passion for equine health and veterinary care. Its kind of cumbersome, but I have two on it, and they are doing better. Avoiding Allergies White believes that while further research in horses is warranted, veterinarians should consider latex exposure a potential risk to equine respiratory health. Many allergens can cause skin reactions. Oclacitinib, a Janus kinase inhibitor, has become an important drug in the management of allergic pruritus. In fact, in our recent study evaluating almost 400 potential allergens, latex proteins were the most significant allergens for diagnosing severe equine asthma.. The only FDA-approved equine PSGAG. @stb its definitely not cheap. Even though the drug is currently labeled for use in dogs (with allergic dermatitis), initial studies show that horses absorb it well, Fultz says. Vet Dermatol 2013;24(5):479-e114. Fortunately, these side effects are relatively uncommon. Apoquel For Dogs: Dosage Apoquel comes in three tablet sizes: 3.6mg, 5.4mg, and 16mg. If she suspects a product or ingredient to be the source of an allergic reaction, Fultz recommends performing elimination trials. 15. In a 3-week trial, the combination of oclacitinib and cyclosporine did not show an increased risk for adverse effects. Panteri A, Strehlau G, Helbig R, et al. In the past 5 years, however, oclacitinib (Apoquel; zoetisus.com), a Janus kinase (JAK) inhibitor, has become another important drug in the management of allergic pruritus. Successful treatment of atopic dermatitis with the JAK1 inhibitor oclacitinib. Some dogs exhibit increased pruritus when the dosage is reduced to once daily. 26. Assuming you cannot contact your vet: For hives or possible allergic airway disease (heaves), for a 1000 lb horse, give 5-10 tabs of 25mg diphenydramine crushed up and mixed in water and dosed in a syringe orally (by mouth). Please select your state below. 21. Clenbuterol should only be used short-term, since it will stop working with long-term administration. The dose of APOQUEL tablets is 0.4 mg/kg to 0.6 mg oclacitinib/kg body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Works on all common sources of allergens. Hay replacement consists of any of the following: a complete pelleted diet, soaked alfalfa cubes, hay pellets, or possibly a bagged forage product like Chaffhaye. Topical suspension administered in the ear. We have had variable results with this treatmet. The Vet had put her on Apoquel as an initial dose for 10 days tapering off. Preventing bites is key, because itching-inflicted injury to hair follicles and skin can take months to heal. Aymeric E, Bensignor E. A case of presumed autoimmune subepidermal blistering dermatosis treated with oclacitinib. She adds, however, that some horses allergy signs are so dramatic that corticosteroids are the most logical choice, at least initially. These molecules are responsible for the appearance of clinical signs commonly associated with allergies, such as itching., Horses environments are full of substances that can trigger the immune system and cause allergies. Equine Asthma- yep, that's the new name for "heaves," "RAO," "COPD" or whatever else we've called it over the years! Drake GJ, Nuttall T, Lpez J, et al. More studies are necessary to confirm oclacitinibs effects in non-allergic diseases and what other immune-mediated mechanisms may be involved. Several reports of successful use of oclacitinib to treat other diseases have been published.22-29 They include several cases of immune-mediated vascular diseases: idiopathic ear tip vasculitis in 4 dogs26 and ischemic dermatopathy in 6 dogs.28,29 In these reports, other classic medications had failed to control the disease until oclacitinib was added. The concentration of the drug is 500 mg/ml. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. The compounded medications featured in this content have been prescribed and/or administered by prescribers who work with Wedgewood Pharmacy. That was 5-6 years ago now. Then, doses ranging from 0.4 to 1.2 mg/kg body weight once daily. An antibody called immunoglobulin E (IgE) is produced when the body detects an allergen, says Samuel White, PhD, a professor of equine science at Nottingham Trent University, in England, known for his research on allergen identification and diagnostic development in the horse. Vet Dermatol 2014;25:153 (abstract). You can give your dog Apoquel with or without food. Available As Tablets For use with Canine Strengths 3.6 mg 5.4 mg 16 mg This is interesting. You may give this medicine with or without food. The most common practical starting dosage for many cats is of the 5.4mg tablet, or 2.7mg. For dogs weighing between 10 and 14.9 pounds, give of a 5.4 mg tablet twice daily as dosage. Im hopeful, however, that I will be able to stretch out more so that Im looking at $250 across 8-10 weeks instead. All rights reserved. 6. Apoquel is the brand name of oclacitinib, a dog medication designed to relieve itching associated with allergies in dogs, particularly canine atopic dermatitis. Is it horrendously expensive? Copyright 2023 Today's Veterinary Practice Web DesignbyPHOS Creative. Blood was collected prior to drug administration and at 15 min, 30 min, 45 min, 1, 2, 4, 6, 8 . These animals require the opposite regimen. llergies can develop at any time, in any horse, and for virtually any reason. Cyclosporine, which is approved for the treatment of canine atopic dermatitis, has an onset of efficacy of up to 4 weeks. Fultz adds that over time this process teaches the immune system to tolerate exposure to substances it previously considered irritating. Treatment may then be continued at the same dose given once a day. 25. You can use a nebulizer, an inhaler, or a single-nostril aerosol chamber. This might, down the road, be an easier and less expensive alternative for horse owners. In many cases, symptomatic therapy alone with drugs such as oclacitinib is insufficient to control allergies long-term. Most horses in our area of North Carolina are "Summer-Pasture-Associated" asthma patients, so we recommend starting yearly treatment or management in March or April. I actually have 2 horses now on serum and one I eliminated the food specific allergens from his diet. Apoquel reduces dog itch, and also decreases inflammation, redness, or swelling of the skinso your dog feels better as quickly as possible What is Apoquel Tablet? After that it would be about $250 every 6 weeks or so if I cant further reduce time between pills. Banovic F, Tarigo J, Gordon H, et al. This product is a hand-held device that administers an anti-inflammatory mist into the horses nostril. Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. Hydroxyzine is usually given orally twice to three times daily in dogs, cats, horses and birds. My understanding from my vet and from what Ive read is that in horses theres been a lot of success in spacing out the dosing, but not as much success in lowering the dose amount. As the only FDA-approved equine PSGAG (polysulfated glycosaminoglycan) for degenerative joint disease (DJD) in horses, Adequan i.m. Sometimes it goes overboard and reacts in the face of a generally harmless substancewhich the body begins to recognize as an allergenand an allergic reaction occurs. 22. Vet Dermatol 2019;30(2):110-e30. In fact, in our. Vet Dermatol 2015;26:134 (abstract). 19. APOQUEL FOR DOGS DOSE. found a significant improvement in 76% of horses with skin allergies within one year of using allergen-desensitization serums. Apoquel is sold per tablet in strengths of 3.6 mg, 5.4 mg, or 16 mg. We. Little PR, King VL, Davis KR, et al. 17. Apoquel should be shipped with extreme caution when temperature is below 35 degrees Fahrenheit. According to the manufacturer's dosage chart, a large breed weighing between 130 and 175lbs should take two Apoquel 16mg daily. Frank RK, Galvan BA, Schoell AR, et al. To ensure that it's easy to administer the proper dosage to your dog, this treatment comes in three different dosages. APQ-01043R3, halved to ensure that the ingredients are equally distributed. Helpful steps you can take include providing full-body fly apparel, applying fly spray liberally, avoiding turnout at dusk and dawn, and using fans in stalls to disrupt insect flying patterns. Lopes NL, Campos DR, Machado MA, et al. Dosage and Administration: The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. Adv Vet Dermatol 2017;8:192-198. He stayed on as a faculty member until 2013, when he decided to move back to Switzerland to open his own dermatology clinic in his hometown of Basel in 2014. Eur J Pharmacol 2017;794:20-26. (https://www.zoetispetcare.com) I get $9 back for every 30 pills I order, it goes onto a Mastercard debit card that can only be used at a vets office but I spend plenty of money there. The second option is serum (blood) testing. While oclacitinib is a very effective and fast-acting antipruritic drug, the decision of when to use it depends on various factors. Ive used it on a couple of mine, and I also have some friends who have done it. For more information, please see the full Prescribing Information. For the first two weeks, this is to be given twice per day, and then once per day after the first two weeks for maintenance. You are encouraged to speak with your prescriber as to the appropriate use of any medication. With an online account, access our extensive formulary or over 40,000 unique items - 24 hours a day, 7 days a week. Vet Dermatol 2013;24(6):587-597, e141-142. Licorice Roo t (Glycyrrhiza glabra) This sweet and soothing herb has been used medicinally for over 3,000 years.